Introduction: Schools have become a primary setting for providing mental health care to youths in the U.S. School-based interventions have proliferated, but their effects on mental health and academic outcomes remain understudied. In this study we will implement and evaluate the effects of a flexible multidiagnostic treatment called Modular Approach to Therapy for Children with Anxiety, Depression, Trauma, or Conduct Problems on students' mental health and academic outcomes.Methods and Analysis: This is an assessor-blind randomized controlled effectiveness trial conducted across five (...) school districts. School clinicians are randomized to either MATCH or usual care treatment conditions. The target sample includes 168 youths referred for mental health services and presenting with elevated symptoms of anxiety, depression, trauma, and/or conduct problems. Clinicians randomly assigned to MATCH or UC treat the youths who are assigned to them through normal school referral procedures. The project will evaluate the effectiveness of MATCH compared to UC on youths' mental health and school related outcomes and assess whether changes in school outcomes are mediated by changes in youth mental health.Ethics and Dissemination: This study was approved by the Harvard University Institutional Review Board. We plan to publish the findings in peer-reviewed journals and present them at academic conferences.Clinical Trial Registration:ClinicalTrials.gov ID: NCT02877875. Registered on August 24, 2016. (shrink)

This volume moves beyond ethics as problem-solving or ethics as etiquette to offer a look at ethics in primary care—as opposed to life-or-death—medical care. Professional Ethics and Primary Care Medicine deals with the ethics of routine, day-to-day encounters between doctors and patients. It probes beneath the hard decisions to look at the moral frameworks, habits of thought, and customs of practice that underlie choices. Harmon Smith and Larry Churchill argue that primary care, far from being merely a setting for (...) the rendering of care, provides a new understanding of both physician and patient, and thereby offers a fresh basis for medical ethics. (shrink)

Western aesthetics has privileged contemplation as a necessary condition for authentic aesthetic experience. In contrast, I argue that the adequacy of aesthetic comportment must be measured by the self-presentation of the object in question, shaped by the place from which such presentations issue. Thus, the specific character of many forms of art, particularly in urban contexts, solicits a kind of “distracted” engagement rather than contemplative attention. Distraction is a positive mode of aesthetic engagement. I begin with a critical account of (...) the formalist theories of Kant and Bell as examples of this privileging of contemplative hermeneutics. I then consider Walter Benjamin’s theory of mimesis as a basis for a more fruitful account of aesthetic form, of which certain “distractive” artworks serve as examples. Distraction is an appropriate response to certain presentations, in the face of which absorption would be a kind of aesthetic failure. (shrink)

This paper is a critique of pornography from within the framework of Heideggerian phenomenology. I contend that pornography is a pernicious form of technological discourse in which women are reduced to spectral and anonymous figures fulfilling a universal role, namely that of sexual subordination. Further, the danger of pornography is covered over in the public sphere as a result of the pervasive appeal to its status as mere fantasy. I argue that relegating the problem to the domain of fantasy is (...) superficial and specious at best, inasmuch as fantasy itself is ultimately grounded in everyday reality. When not concealed as innocuous “fantasy,” pornography has been defended under the rubric of “free speech.” One of my aims is to repudiate this approach by revealing it as grounded in a highly suspect and self-contradictory phallocentric view of language. Rae Langton’s (2009) recently published collection of essays on pornography attacks the problem largely in terms of “objectification” and the Austinian notion of “illocutionary disablement” from a position of authority. In this paper, I too confront the issues of language, objectification, and authority, but as articulated by means of Heidegger’s critique of technology. (shrink)

_Reconfigures classic aesthetic concepts in relation to the novelty introduced by virtual bodies._.

The aims of this paper are twofold: to critique Graham Harman’s avowedly nonrelational object-oriented ontology from the shared relational vantage of ethics, social philosophy, and feminist new materialism; and to articulate the metaphysical basis for a materialist ontology that serves at once as a posthumanist metaethic, or, as I call it, proto-ethic. The nascent movements of speculative realism and object-oriented ontology suggest some fruitful strategies for challenging the anthropocentrism of the post-Kantian philosophical landscape. They do so, however, by simultaneously foreclosing (...) the possibility of thinking with these strategies to address moral and political problems, insofar as they characterize the real as fundamentally nonrelational. I argue that Harman’s adopted noumenalism is ultimately self-undermining, and offer as an alternative a materialist account of reality as intrinsically phenomenal, where phenomenality is unpacked as the excessive, ongoing source of proto-ethical norms to which every human ethical system implicitly appeals. (shrink)

The aims of this paper are twofold: (1) to critique Graham Harman’s avowedly nonrelational object-oriented ontology from the shared relational vantage of ethics, social philosophy, and feminist new materialism; and (2) to articulate the metaphysical basis for a materialist ontology that serves at once as a posthumanist metaethic, or, as I call it, proto-ethic. The nascent movements of speculative realism and object-oriented ontology suggest some fruitful strategies for challenging the anthropocentrism of the post-Kantian philosophical landscape. They do so, however, by (...) simultaneously foreclosing the possibility of thinking with these strategies to address moral and political problems, insofar as they characterize the real as fundamentally nonrelational. I argue that Harman’s adopted noumenalism is ultimately self-undermining, and offer as an alternative a materialist account of reality as intrinsically phenomenal, where phenomenality is unpacked as the excessive, ongoing source of proto-ethical norms to which every human ethical system implicitly appeals. (shrink)

In this response paper I defend an alternative position to both Jennifer McMahon’s neo-Kantian view on the aesthetics of perceptual experience, and the sense-data theory that she rightly repudiates. McMahon argues that sense perception is informed by concepts “all the way out,” and that the empiricist notion of unmediated sensuous access to entities in the world is untenable. She further claims that art is demanding inasmuch as it compels one to engage in an open-ended, cognitive interpretive process with sensuous phenomena, (...) and that it is this very process that opens up a space for critique of the entrenched representational concepts by which we navigate the world. In contrast, I argue that the sensuous itself is a source of demand. Perceptual objects, in virtue of their material constitution, are inexhaustible plexuses of meaning that demand a kind of sensuous, interpretive response on the part of our bodily posture and orientation. Works of art offer opportunities for critique insofar as they reveal dimensions of sensuous reality hitherto covered over by status quo conceptual distributions. McMahon is right that sensuous objects are never simply given. But, I claim, she is wrong to suggest that it is only by way of conceptual mediation that we make contact with the world. On the contrary, the sensuous self-presentation of things is always at the same time a demand on our sensory apparatus that resists encapsulation by concepts. (shrink)

Allen Carlson has argued that a proper aesthetics of nature must judge nature for ‘what it is’, and that such judgements must be informed by a scientific understanding of nature, in particular, one shaped by the science of ecology. Carlson uses these claims to support his theory of positive aesthetics. This paper argues that there are problems in this view. First, it misunderstands ecology, thereby adopting a view of the natural world that holds it to be much more integrated than (...) it is. Second, it ignores an even more fundamental science of nature, evolution. Thus, it misunderstands both ecology and nature. An alternative to this view would be an aesthetics based on an evolutionary understanding of nature, which holds that, although there are many functional wholes in nature, there is also significant conflict, disintegration, and incongruent scales. A proper aesthetics of nature must take these conflicts into account. The paper ends with a sketch of an aesthetic theory based on the science of evolution. (shrink)

This article aims to compare the national legal systems that regulate biomedical research in an industrialized country (United States) and a developing country (Venezuela). A new international order is emerging in which Europe, Japan and the United States (US) are revising common guidelines and harmonizing standards. In this article, we analyze – as an example – the US system. This system is controlled by a federal agency structured to regulate research funded by the federal government uniformly, either in the US (...) or abroad. In contrast, in Venezuela, a developing country, the creation of a centralized system is a slow process. Different types of ethical committees review research projects using non-uniform criteria. Consequently, various parallel organizations that conduct biomedical research, such as universities, research institutes and private hospitals have diverse regulations operating at a local level. Thus, the most relevant difference between the Venezuelan and the US systems is the degree of standardization. In the US, the review process is performed by institutional review boards (IRBs), which have a similar organization and maintain relationships with a centralized agency, following standard regulations. Although new proposals for establishing national regulations are currently being considered in Venezuela, the success of these initiatives will depend on promoting governmental efforts to create a more structured centralized system supported by a national regulatory framework. This system will need governmental financial support at all levels. This article proposes an integrated system to regulate research with human participants in Venezuela and other developing countries. (shrink)

Supreme Audit Institutions (SAIs) investigate the regularity (conformity to legislation) and performance (economy, efficiency, and effectiveness) of central government policies and administration through the instrument of accountability. Both types of audit have their own research process and set of standards. This article deals with the question of whether this distinction inhibits a proper appraisal of policy and administration and investigates the possibilities for SAIs to attain more integrated assessment procedures. This question is of vital importance, not only to SAIs but (...) to any controlling and inspecting body, whether political or administrative. (shrink)

If business requires ethical solutions that are viable in the liminal landscape between concepts and corporate office, then business ethics and corporate social responsibility should offer tools that can survive the trek, that flourish in this well-traveled, but often unarticulated, environment. Indeed, feminist ethics produces, accesses, and engages such tools. However, work in BE and CSR consistently conflates feminist ethics and feminine ethics and care ethics. I offer clarification and invoke the analytic power of three feminist ethicists 'in action' whose (...) investigations into the "grey zones" of harms; identity and representational conventions; and "asymmetrical reciprocity" harmonize with business ethics' requirements. (shrink)

This work is of the view that the question of being is not only a problem in Western philosophy but also in African philosophy. It, therefore, posits that being is that which is and has both abstract and concrete aspect. The work arrives at this conclusion by critically analyzing and evaluating the views of some key African philosophers with respect to being. With this, it discovers that the way that these African philosophers have postulated the idea of being is in (...) the same manner like their Western philosophers whom they tried to criticize. This work tries to synthesize the notions of beings of these African philosophers in order to reach at a better understanding of being. This notion of being leans heavily on Asouzu’s ibuanyidanda ontology which does not bifurcate or polarize being, but harmonizes entities or realities that seem to be contrary or opposing in being. (shrink)

A pair of harmonic oscillators come in contact and then separate. This could be a model of an atom encountering an electromagnetic field. We explore the coherence properties of the resulting state as a function of the sort of initial condition used. A surprising result is that if one imagines a large collection of these objects repeatedly coming in contact and separating, the asymptotic distribution functions are not Boltzmann distributions, but rather exponentials with the same rate of dropoff.

As past president of both the History of Science Society and the American Society of Church History, Ronald L. Numbers is uniquely qualified to assess the historical relations between science and Christianity. In this collection of his most recent essays, he moves beyond the clichés of conflict and harmony to explore the tangled web of historical interactions involving scientific and religious beliefs. In his lead essay he offers an unprecedented overview of the history of science and Christianity from the perspective (...) of the ordinary people who filled the pews of churchesor loitered around outside. Unlike the elite scientists and theologians on whom most historians have focused, these vulgar Christians cared little about the discoveries of Copernicus, Newton, and Einstein. Instead, they worried about the causes of the diseases and disasters that directly affected their lives and about scientists preposterous attempts to trace human ancestry back to apes. Far from dismissing opinion-makers in the pulpit, Numbers closely looks at two the most influential Protestant theologians in nineteenth-century America: Charles Hodge and William Henry Green. Hodge, after decades of struggling to harmonize Gods two revelationsin nature and in the Biblein the end famously described Darwinism as atheism. Green, on the basis of his careful biblical studies, concluded that Ussher's chronology was unreliable, thus opening the door for Christian anthropologists to accommodate the subsequent discovery of human antiquity. In Science without God Numbers traces the millennia-long history of so-called methodological naturalism, the commitment to explaining the natural world without appeals to the supernatural. By the early nineteenth century this practice was becoming the defining characteristic of science; in the late twentieth century it became the central point of attack in the audacious attempt of intelligent designers to redefine science. Numbers ends his reassessment by arguing that although science has markedly changed the world we live in, it has contributed less to secularizing it than many have claimed. Taken together, these accessible and authoritative essays form a perfect introduction to Christian attitudes towards science since the 17th century. (shrink)

Music training is associated with enhanced executive function but little is known about the extent to which harmonic aspects of musical training are associated with components of executive function. In the current study, an array of cognitive tests associated with one or more components of executive function, was administered to young adult musicians and non-musicians. To investigate how harmonic aspects of musical training relate to executive function, a test of the ability to compose a four-part harmony was developed and administered (...) to musicians. We tested the working hypothesis that musicians would outperform non-musicians on measures of executive function, and that among musicians, the ability to harmonize would correlate positively with measures of executive function. Results indicate that musicians outperformed non-musicians on the Tower of London task, a measure of planning and problem-solving. Group differences were not detected on tasks more selective for inhibitory control, conflict resolution, or working memory. Among musicians, scores on the harmony assessment were positively correlated with performance of the Tower of London task. Taken together, the current results support a strong relationship between musicianship and planning and problem solving abilities, and indicate that the ability to harmonize is associated with components of executive function contributing to planning and problem solving. (shrink)

BackgroundIn research ethics, the most basic question would always be, “which is an ethical issue, which is not?” Interestingly, depending on which ethics guideline we consult, we may have various answers to this question. Though we already have several international ethics guidelines for biomedical research involving human participants, ironically, we do not have a harmonized document which tells us what these various guidelines say and shows us the areas of consensus. In this manuscript, we attempted to do just that.MethodsWe extracted (...) the imperatives from five internationally-known ethics guidelines and took note where the imperatives came from. In doing so, we gathered data on how many guidelines support a specific imperative.ResultsWe found that there is no consensus on the majority of the imperatives and that in only 8.2 % of the imperatives were there at least moderate consensus. Of the 12 clusters, Informed Consent has the highest level of consensus and Research Collaboration and Regulatory Sanctions have the least.ConclusionThere was a lack of consensus in the majority of imperatives from the five internationally-known ethics guidelines. This may be partly explained by the differences among the guidelines in terms of their levels of specification as well as conceptual/ideological differences. (shrink)

The twelfth century was a period of transmission and absorption of Arabic learning though it filtered outside of the Arabic world as early as the second half of the tenth century. In general, the lure of Spain began to act only in the twelfth century, and the active impulse toward the spread of Arabic mathematics came from beyond the Pyrenees and from men of diverse origins. The chief names are Adelard of Bath, Robert of Chester, Hermann of Carinthia and Gerard (...) of Cremona. In this time the Latin world became acquainted with the Hindu numerals, the Arabic Algebra and Euclid'sElements. However, not only Spain, but also the Norman kingdom of southern Italy and Sicily occupies a position of peculiar importance, though the works of the translators did not become very influential. There were made direct translations from Greek into Latin. One had to wait a century more to obtain a translation from Greek into Latin of the chief Archimedean scientific and mathematical treatises by William of Moerbeke. In the thirteenth century Fibonacci and Jordanus Nemorarius stand at the threshold of European mathematics. Not only was Fibonacci the first to explain Arabic arithmetic, but his works, especially his later ones, contain many original ideas. Jordanus continued the Greco-Roman tradition rather than the Greco-Arabic one, but he did so with much independence. To Nicole Oresme (fourteenth century) was due a broadened view of proportionality, a geometric proof to determine the summation of convergent infinite series and the proof, evidently the first in the history of mathematics, that the harmonic series is divergent. The Configuration Doctrine was treated by Merton College authors and by Oresme. In the fifteenth century theDe triangulis omnimodis of Regiomontan, a systematic account of the methods for solving triangles, marked the rebirth of trigonometry. (shrink)

There are a number of problematic features within the current treatment of time in physical theories, including the “timelessness” of the Universe as encapsulated by the Wheeler–DeWitt equation. This paper considers one particular investigation into resolving this issue; a conditional probability interpretation that was first proposed by Page and Wooters. Those authors addressed the apparent timelessness by subdividing a faux Universe into two entangled parts, “the clock” and “the remainder of the Universe”, and then synchronizing the effective dynamics of the (...) two subsystems by way of conditional probabilities. The current treatment focuses on the possibility of using a realistic clock system; namely, a coherent-state description of a damped harmonic oscillator. This clock proves to be consistent with the conditional probability interpretation; in particular, a standard evolution operator is identified with the position of the clock playing the role of time for the rest of the Universe. Restrictions on the damping factor are determined and, perhaps contrary to expectations, the optimal choice of clock is not necessarily one of minimal damping. (shrink)

By making use of the method of moments we study some aspects of the statistical behavior of the nonrelativistic harmonic oscillator according to stochastic electrodynamics. We show that the random rotations induced on the particle by the zero-point field account for the magnitude of the spin of the electron, the result differing from the correct one(3/4)h 2 by a factor of2. Assuming that the measurement of a spin projection may be effectively taken into account by considering the action of only (...) the subensemble of the field with the corresponding circular polarization, the calculated value of the spin projection comes out to be the correct one within a factor of order unity. The radiative corrections give rise to both the Lamb shift and the anomalous magnetic moment of the electron, the latter being evaluated to within a factor of2. The magnetic and gyromagnetic properties of the electron come out to be in agreement with quantum mechanics. Interference effects are shown to occur when evaluating the average value of the square of the angular momentum. (shrink)

In his commentary on Aristotle’s Rhetoric al-Fārābī harmonizes Plato and Aristotle in terms of philosophic education by ordering Aristotle’s eight logical works onto Plato’s famous image of the cave. He represents the way out of the cave with Aristotle’s four logical works of ascent and the return into the cave through Aristotle’s four logical works of the descent. Al-Fārābī’s image of ascent and descent also alludes to Socrates’ conception of protreptic education in Book VII of the Republic. In essence, protreptic (...) education consists in the Socratic art that freely turns the soul from the images and political interpretations of things to being itself. In this essay I argue that for al-Fārābī the four logical works of ascent guide the soul to free itself from its habituations so as to contemplate real beings, particularly the good of one’s own soul and the souls of one’s fellow citizens. Yet the ruler needs to use the arts of “descent,” as demonstrated by Thrasymachus, in order to rule the city well. The way of Socrates consists of the logical methods used to come to possess knowledge of being, while the way of Thrasymachus comprises the methods of persuasion to habituate citizens and protect the philosophic quest for the truth. Al-Fārābī, I conclude, combines the way of Socrates and the way of Thrasymachus in order to show that both ways are useful and necessary for good governance. (shrink)

More laws obtain in the world,it appears, than just those of microphysics –e.g. laws of genetics, perceptual psychology,economics. This paper assumes there indeedare laws in the special sciences, and notjust scrambled versions of microphysical laws. Yet the objects which obey them are composedwholly of microparticles. How can themicroparticles in such an object lawfully domore than what is required of them by the lawsof microphysics? Are there additional laws formicroparticles – which seems to violate closureof microphysics – or is the ``more'' (...) acoincidental outcome of microphysics itself? This paper argues that the appearance ofviolation is illusory, and the worry aboutcoincidence misleading. We cannot expect tounderstand the special sciences at the level ofthe microparticles. (shrink)

Here, we offer concrete illustrations of the state determination method developed abstractly in Part I of this work. Quorums are found for finite-dimensional magnetic multipole problems as well as for the harmonic oscillator with an energy cutoff. There is, in addition, a discussion of general procedures for empirically distinguishing pure states from mixed states.

This chapter contains sections titled: Attentiveness Awareness of the Circumstances of Action Acknowledging the Autonomy of Others Respecting Complexity Memory Respecting Individuality Rethinking the Past The Habit of Resourcefulness Kantian Mutual Respect Genuineness and Insight Sensitivity to the Context of Discourse Excessive Attentiveness The Diversity of Intentional Action.

Paterson sees Bruno as a philosopher of rational thought and the open society, martyred by the forces of social constraint. She outlines his cosmology and shows how his theory of knowledge and his ethics derive from it. For Bruno, the fabric of the universe is a dynamic, spirited, divine power which continually generates the infinite multiplicity of things and draws them back into itself. Man's intellect mirrors the universal motion of creation and corruption, drawing ideas from sensibility as the divine (...) intellect draws the natural species from matter. Since the good and the true coincide in the divine unity, man's good consists in harmonizing them and so mirroring the divine. He whose efforts are directed to this harmony and to expanding constantly his knowledge and achievements is universal man. Paterson argues that a rational ethic is implicit in Bruno's thought. Also implicit is the method of modern science, i.e., a speculative leap, followed by empirical testing. The author points out that much work remains to be done by translators, editors, historians, and philosophers before any stable assessment of Bruno can be made.--L. G. (shrink)

ABSTRACT This paper examines the claim that what is ‘really’ good for business will in the end harmonize with the requirements of morality. In searching for a plausible interpretation of what might be ‘really’ good for a business enterprise, the paper explores analogies to traditional philosophical accounts of the ‘true good’ of man. The conclusion is that while such accounts can make sense of the claim that a person's true good requires a moral commitment, they can suggest no solution applicable (...) to business. The reason is that the analogy between natural persons and business enterprises breaks down at a crucial point. It follows that any radical improvement in the moral quality of business activity cannot come from appealing to a ‘true good’ of business. And since external means of control are not sufficient, the paper concludes that we must rely on the moral motivation of individuals filling positions in business. What is indicated then is the need for a strengthened consciousness of the range of freedom and responsibility of persons in their work roles. (shrink)

A sequel to Global Trade Analysis: Modeling and Applications, this new volume presents the technical aspects of the Global Trade Analysis Program's global dynamic framework and its applications within important global policy issues. The book covers a diverse set of topics including trade reform, growth, investment, technology, demographic change and the environment. Environmental issues are particularly well-suited for analysis with GDyn, and this volume covers its uses with climate change, resource use and technological progress in agriculture. Other applications presented in (...) the book focus on integration issues such as rules governing foreign investment, e-commerce regulations, trade in services, harmonization of technical standards, sanitary and photo-sanitary regulations, streamlining of customs procedures, and demographic change and migration. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Religion, the Globalization of War, and Restorative JusticeNathan TierneyAs the pace of globalization increases, the world's religions find themselves in a perilous dilemma that they have yet to resolve in either practical or conceptual terms. On the one hand, the globalization of markets exerts a powerful pressure toward consumerist and materialist values, which undermine and undercut religious perspectives and sensibilities. On the other hand, the globalization of war heightens (...) the intensity of these religious perspectives and sensibilities, and distorts them in the direction of violence and religious extremism. This dilemma plays itself out in different ways in the developed and developing world, but, as the term "globalization" indicates, it is a problem for all of us. Governments, in developing countries especially, often find themselves forced to choose between one horn of the dilemma or the other, with often disastrous results as they take one or the other side in a "West versus the rest" scenario. In the long run, the only viable solution is one that addresses both horns of the dilemma at the same time, and this is possible only if, in turn, religions themselves become truly global. This will require a large-scale and focused cooperative effort in which the religions of the world actively and jointly engage with both problems, working with governments, NGOs, religious communities, and interfaith groups to harmonize religious life with economics and to promote a culture of peace and justice.Because "globalization" is a familiar term in relation to markets, I'll begin by clarifying what I mean by the globalization of war. There are two main aspects to this phenomenon. First, the term refers to a specific transformation in the nature, purposes, and conditions of warfare brought about by the forces of globalization. By globalization I mean the growing trend of the world's cultural, economic, and political forces to bypass national borders and operate on a world scale. This process creates new possibilities for both integration and conflict. When that conflict passes beyond the possibility of diplomatic negotiation, we have the conditions for globalized war. Globalized war is not necessarily world war. It can be relatively local in its sphere of combat; for example, the U.S. invasion of Afghanistan was a collective response to a worldwide threat of terrorism. What makes it a globalized war, as distinct from international war, is the global nature of the forces that produced it and [End Page 79] are affected by it. Globalized war in this sense has come only lately onto the scene, but its scale and impact is likely to grow in the coming century.The second aspect of the globalization of war is the tendency of conflict to mutate beyond the interests and concerns of nation-states and be taken up by broader civilizational units, even if they were not originally a response to global pressures. The most likely trajectory for this mutation has been well described by Samuel P. Huntington in his influential article "The Clash of Civilizations" (1993) and his book-length treatment of the same subject (1997). Huntington argues that the fault lines of conflict will not be primarily ideological or economic but cultural, where "cultural" is to be understood at its broadest level—the level of civilizations. He divides the world into seven or eight competing civilizations: Western, Sinic, Japanese, Hindu, Islamic, Orthodox, Latin American, and possibly African. Societies sharing cultural affinities will cooperate with one another, and the attempt by the West to universalize its dominant version of consumer capitalism and liberal democracy will be resisted in an increasingly determined way—eventually to the point of outright war: "the next world war, if there is one, will be a war between civilizations."1In Huntington's analysis, then, the globalization of war refers to a coming clash of civilizations. He believes that religion will play a central role in this clash as the focal point of civilizations: "Civilizations are differentiated from each other by history, language, culture tradition and, most important, religion."2 While Western civilization has experienced several decades of decline and decay, in both its cultural unity and its sense of identity, other civilizations have grown both in economic terms and... (shrink)

ABSTRACT This article examines the under-researched figure A.W. Rehberg in his exchange with Kant over the relationship between theory and practice in the philosophy of right. I argue that Rehberg raises, what I call, two problems of political matter which attempt to show that Kant's overly formal approach to political theory cannot justifiably determine political practice. The first problem is the problem of positive determinations of right, rather than merely negative prohibitions. Rehberg takes this to mean that Kant cannot determine (...) us to a specific form of constitution. I argue that Kant's innovation of intelligible property functions as a response to this critique in that it provides the possibility of synthetic propositions of right a priori. Second, Rehberg insists that an a priori system of right cannot relate to already formed historical communities. Here Kant's response comes close to agreeing with Rehberg as Kant takes prudential or historical reasoning to harmonize with the demands of a priori right in order to applied to the sensible world. Kant, in this instance, comes closer to Rehberg by denying centralized enlightened monarchy and the reliance on natural and historical development for the application of right. (shrink)

ABSTRACT This article aims to compare the national legal systems that regulate biomedical research in an industrialized country (United States) and a developing country (Venezuela). A new international order is emerging in which Europe, Japan and the United States (US) are revising common guidelines and harmonizing standards. In this article, we analyze – as an example – the US system. This system is controlled by a federal agency structured to regulate research funded by the federal government uniformly, either in the (...) US or abroad. In contrast, in Venezuela, a developing country, the creation of a centralized system is a slow process. Different types of ethical committees review research projects using non‐uniform criteria. Consequently, various parallel organizations that conduct biomedical research, such as universities, research institutes and private hospitals have diverse regulations operating at a local level. Thus, the most relevant difference between the Venezuelan and the US systems is the degree of standardization. In the US, the review process is performed by institutional review boards (IRBs), which have a similar organization and maintain relationships with a centralized agency, following standard regulations. Although new proposals for establishing national regulations are currently being considered in Venezuela, the success of these initiatives will depend on promoting governmental efforts to create a more structured centralized system supported by a national regulatory framework. This system will need governmental financial support at all levels. This article proposes an integrated system to regulate research with human participants in Venezuela and other developing countries. (shrink)

The Gauss-Hertz principle is extended by the use of existence conditions (or constraints) to obtain a hierarchy of differential equations which include all classical equations of continuum mechanics (including electrodynamics) and the harmonic oscillator potential as well.

The target article emphasizes the need to identify psychological mechanisms underlying grandparental investment, particularly in low-risk family contexts. We extend this approach by addressing the changing demands of balancing work and family in low-risk families. Taking a lifespan psychological perspective, we identify additional motivators and potential benefits of grandparental investment for grandparents themselves and for subsequent generations.

We present the Dirac and Laplacian operators on Clifford bundles over space–time, associated to metric compatible linear connections of Cartan–Weyl, with trace-torsion, Q. In the case of nondegenerate metrics, we obtain a theory of generalized Brownian motions whose drift is the metric conjugate of Q. We give the constitutive equations for Q. We find that it contains Maxwell’s equations, characterized by two potentials, an harmonic one which has a zero field (Bohm-Aharonov potential) and a coexact term that generalizes the Hertz (...) potential of Maxwell’s equations in Minkowski space.We develop the theory of the Hertz potential for a general Riemannian manifold. We study the invariant state for the theory, and determine the decomposition of Q in this state which has an invariant Born measure. In addition to the logarithmic potential derivative term, we have the previous Maxwellian potentials normalized by the invariant density. We characterize the time-evolution irreversibility of the Brownian motions generated by the Cartan–Weyl laplacians, in terms of these normalized Maxwell’s potentials. We prove the equivalence of the sourceless Maxwell equation on Minkowski space, and the Dirac-Hestenes equation for a Dirac-Hestenes spinor field written on Minkowski space provided with a Cartan–Weyl connection. If Q is characterized by the invariant state of the diffusion process generated on Euclidean space, then the Maxwell’s potentials appearing in Q can be seen alternatively as derived from the internal rotational degrees of freedom of the Dirac-Hestenes spinor field, yet the equivalence between Maxwell’s equation and Dirac-Hestenes equations is valid if we have that these potentials have only two components corresponding to the spin-plane. We present Lorentz-invariant diffusion representations for the Cartan–Weyl connections that sustain the equivalence of these equations, and furthermore, the diffusion of differential forms along these Brownian motions. We prove that the construction of the relativistic Brownian motion theory for the flat Minkowski metric, follows from the choices of the degenerate Clifford structure and the Oron and Horwitz relativistic Gaussian, instead of the Euclidean structure and the orthogonal invariant Gaussian. We further indicate the random Poincaré–Cartan invariants of phase-space provided with the canonical symplectic structure. We introduce the energy-form of the exact terms of Q and derive the relativistic quantum potential from the groundstate representation. We derive the field equations corresponding to these exact terms from an average on the invariant state Cartan scalar curvature, and find that the quantum potential can be identified with 1 / 12R(g), where R(g) is the metric scalar curvature. We establish a link between an anisotropic noise tensor and the genesis of a gravitational field in terms of the generalized Brownian motions. Thus, when we have a nontrivial curvature, we can identify the quantum nonlocal correlations with the gravitational field. We discuss the relations of this work with the heat kernel approach in quantum gravity. We finally present for the case of Q restricted to this exact term a supersymmetric system, in the classical sense due to E.Witten, and discuss the possible extensions to include the electromagnetic potential terms of Q. (shrink)

Some children living with life-shortening medical conditions may wish to attend school without the threat of having resuscitation attempted in the event of cardiopulmonary arrest on the school premises. Despite recent attention to in-school do-not-attempt-resuscitation (DNAR) orders, no assessment of state laws or school policies has yet been made. We therefore sought to survey a national sample of prominent school districts and situate their policies in the context of relevant state laws. Most (80%) school districts sampled did not have policies, (...) regulations, or protocols for dealing with student DNARs. A similar majority (76%) either would not honor student DNARs or were uncertain about whether they could. Frequent contradictions between school policies and state laws also exist. Consequently, children living with life-shortening conditions who have DNARs may not have these orders honored if cardiopulmonary arrest were to occur on school premises. Coordinated efforts are needed to harmonize school district, state, and federal approaches in order to support children and families' right to have important medical decisions honored. (shrink)

Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...) OBO principles were not originally encoded in a precise fashion, and interpretation was subjective. Here we show how we have addressed this by formally encoding the OBO principles as operational rules and implementing a suite of automated validation checks and a dashboard for objectively evaluating each ontology’s compliance with each principle. This entailed a substantial effort to curate metadata across all ontologies and to coordinate with individual stakeholders. We have applied these checks across the full OBO suite of ontologies, revealing areas where individual ontologies require changes to conform to our principles. Our work demonstrates how a sizable federated community can be organized and evaluated on objective criteria that help improve overall quality and interoperability, which is vital for the sustenance of the OBO project and towards the overall goals of making data FAIR. Competing Interest StatementThe authors have declared no competing interest. (shrink)

Laws in the 20 jurisdictions studied for this project display many similar approaches to protecting privacy in biobank research. Although few have enacted biobank-specific legislation, many countries address biobanking within other laws. All provide for some oversight mechanisms for biobank research, even though the nature of that oversight varies between jurisdictions. Most have some sort of controlled access system in place for research with biobank specimens. While broad consent models facilitate biobanking, countries without national or federated biobanks have been slow (...) to adopt broad consent. International guidelines have facilitated sharing and generally take a proportional risk approach, but many countries have provisions guiding international sharing and a few even limit international sharing. Although privacy laws may not prohibit international collaborations, the multi-prong approach to privacy unique to each jurisdiction can complicate international sharing. These symposium issues can serve as a resource for explaining the sometimes intricate privacy laws in each studied jurisdiction, outlining the key issues with regards to privacy and biobanking, and serving to describe a framework for the process of harmonization of privacy laws. (shrink)

Scientists now agree that common diseases arise through interactions of genetic and environmental factors, but there is less agreement about how scientific research should account for these interactions. This paper examines the politics of quantification in gene–environment interaction research. Drawing on interviews and observations with GEI researchers who study common, complex diseases, we describe quantification as an unfolding moral economy of science, in which researchers collectively enact competing “virtues.” Dominant virtues include molecular precision, in which behavioral and social risk factors (...) are moved into the body, and “harmonization,” in which scientists create large data sets and common interests in multisited consortia. We describe the negotiations and trade-offs scientists enact in order to produce credible knowledge and the forms of discipline that shape researchers, their practices, and objects of study. We describe how prevailing techniques of quantification are premised on the shrinking of the environment in the interest of producing harmonized data and harmonious scientists, leading some scientists to argue that social, economic, and political influences on disease patterns are sidelined in postgenomic research. We consider how a variety of GEI researchers navigate quantification’s productive and limiting effects on the science of etiological complexity. (shrink)

The study of business ethics has led to the development of various principles that are the foundation of good and ethical business practices. A corresponding study of Information Technology (IT) professionals’ ethics has led to the conclusion that good ethics in the development and uses of information technology correspond to the basic business principle that good ethics is good business. Ergo, good business ethics practiced by IT professionals is good IT ethics and vice versa. IT professionals are professionals in businesses; (...) a difficulty presented to these professionals, however, is the number and diversity of codes of ethics to which they may be held. Considering the existence of several formalized codes of ethics prepared by various IT professionals’ associations, a more harmonized approach seems more reasonable. This paper attempts to present a review of the purpose of codes of ethics, the persons who should be covered by such codes and to organize codes of ethics for business in general and IT professionals in particular and to make the argument that, once again, good ethics is good business practice, regardless of the profession or occupation concerned. (shrink)

Rereading Renée C. Fox's “A Sociological Perspective on Organ Transplantation and Hemodialysis,” published in 1970, one is likely to be struck more by continuity than by change. The most pressing of the social, policy, and ethical concerns that Fox raised remain problematic fifty years later. We still struggle with scientific and clinical uncertainty, with the boundary between experimentation and therapy, and with the cost of organ replacement therapies and disparities in how they are allocated. We still have an imperfect understanding (...) of transplant immune responses. We still debate when a potential donor “actually” dies, and we still seem to think better empirical criteria could harmonize the diverse religious, cultural, and socioeconomic values of patients, providers, third‐party payers, and policy‐makers. Organ transplantation was for Fox both a particular case unfolding in time and an entryway for discussing the difficult moral questions presented by many new medical technologies in a context of high demand and limited resources. (shrink)